Intramuscular Injection of AAV8 in Mice and Macaques Is Associated with Substantial Hepatic Targeting and Transgene Expression

Intramuscular (IM) administration of adeno-associated viral (AAV) vectors has entered the early stages of clinical development with some success, including the first approved gene therapy product in the West called Glybera. In preparation for broader clinical development of IM AAV vector gene therap...

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Publicat a:PLoS One
Autors principals: Greig, Jenny A., Peng, Hui, Ohlstein, Jason, Medina-Jaszek, C. Angelica, Ahonkhai, Omua, Mentzinger, Anne, Grant, Rebecca L., Roy, Soumitra, Chen, Shu-Jen, Bell, Peter, Tretiakova, Anna P., Wilson, James M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230988/
https://ncbi.nlm.nih.gov/pubmed/25393537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112268
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