Impact of intravenous infusion time on AAV8 vector pharmacokinetics, safety, and liver transduction in cynomolgus macaques

Systemically delivered adeno-associated viral (AAV) vectors are now in early-phase clinical trials for a variety of diseases. While there is a general consensus on inclusion and exclusion criteria for each of these trials, the conditions under which vectors are infused vary significantly. In this st...

Full description

Saved in:
Bibliographic Details
Published in:Mol Ther Methods Clin Dev
Main Authors: Greig, Jenny A, Nordin, Jayme ML, Bote, Erin, Makaron, Leah, Garnett, Mason E, Kattenhorn, Lisa M, Bell, Peter, Goode, Tamara, Wilson, James M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142508/
https://ncbi.nlm.nih.gov/pubmed/27933307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.79
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items