The Pleiotropic Effects of Natural AAV Infections on Liver-directed Gene Transfer in Macaques

Adeno-associated viral (AAV) vectors hold great potential for liver-directed gene therapy. Stable and high levels of transgene expression have been achieved in many murine models. Systemic delivery of AAV vectors in nonhuman primates (NHPs) that are natural hosts of AAVs appear to be challenging due...

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Main Authors: Wang, Lili, Calcedo, Roberto, Wang, Huan, Bell, Peter, Grant, Rebecca, Vandenberghe, Luk H, Sanmiguel, Julio, Morizono, Hiroki, Batshaw, Mark L, Wilson, James M
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2009
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839221/
https://ncbi.nlm.nih.gov/pubmed/19888196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.245
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