The Pleiotropic Effects of Natural AAV Infections on Liver-directed Gene Transfer in Macaques

Adeno-associated viral (AAV) vectors hold great potential for liver-directed gene therapy. Stable and high levels of transgene expression have been achieved in many murine models. Systemic delivery of AAV vectors in nonhuman primates (NHPs) that are natural hosts of AAVs appear to be challenging due...

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書誌詳細
主要な著者: Wang, Lili, Calcedo, Roberto, Wang, Huan, Bell, Peter, Grant, Rebecca, Vandenberghe, Luk H, Sanmiguel, Julio, Morizono, Hiroki, Batshaw, Mark L, Wilson, James M
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2009
主題:
Original Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839221/
https://ncbi.nlm.nih.gov/pubmed/19888196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.245
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