Intramuscular Injection of AAV8 in Mice and Macaques Is Associated with Substantial Hepatic Targeting and Transgene Expression

Intramuscular (IM) administration of adeno-associated viral (AAV) vectors has entered the early stages of clinical development with some success, including the first approved gene therapy product in the West called Glybera. In preparation for broader clinical development of IM AAV vector gene therap...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Greig, Jenny A., Peng, Hui, Ohlstein, Jason, Medina-Jaszek, C. Angelica, Ahonkhai, Omua, Mentzinger, Anne, Grant, Rebecca L., Roy, Soumitra, Chen, Shu-Jen, Bell, Peter, Tretiakova, Anna P., Wilson, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230988/
https://ncbi.nlm.nih.gov/pubmed/25393537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112268
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