Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors

The conversion of somatic cells into pluripotent stem cells via overexpression of reprogramming factors involves epigenetic remodeling. DNA methylation at a significant proportion of CpG sites in induced pluripotent stem cells (iPSCs) differs from that of embryonic stem cells (ESCs). Whether differe...

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Detalhes bibliográficos
Publicado no:Cell Regen
Main Authors: Planello, Aline C, Ji, Junfeng, Sharma, Vivek, Singhania, Rajat, Mbabaali, Faridah, Müller, Fabian, Alfaro, Javier A, Bock, Christoph, De Carvalho, Daniel D, Batada, Nizar N
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230737/
https://ncbi.nlm.nih.gov/pubmed/25408883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-9769-3-4
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