Antioxidant Supplementation Reduces Genomic Aberrations in Human Induced Pluripotent Stem Cells

Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) using oncogenic transcription factors. However, this method leads to genetic aberrations in iPSCs via unknown mechanisms, which may limit their clinical use. Here, we demonstrate that the supplementation of growth media with...

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Autors principals: Ji, Junfeng, Sharma, Vivek, Qi, Suxia, Guarch, Meritxell Espino, Zhao, Ping, Luo, Zhiwei, Fan, Wenxia, Wang, Yu, Mbabaali, Faridah, Neculai, Dante, Esteban, Miguel Angel, McPherson, John D., Batada, Nizar N.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916753/
https://ncbi.nlm.nih.gov/pubmed/24511469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.11.004
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