Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is a malignant pediatric brain tumor associated with dismal outcome. Recent high-throughput molecular studies have shown a high frequency of mutations in histone-encoding genes (H3F3A and HIST1B) and distinctive epigenetic alterations in these tu...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Ahsan, Sama, Raabe, Eric H, Haffner, Michael C, Vaghasia, Ajay, Warren, Katherine E, Quezado, Martha, Ballester, Leomar Y, Nazarian, Javad, Eberhart, Charles G, Rodriguez, Fausto J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229804/
https://ncbi.nlm.nih.gov/pubmed/24894482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-59
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