Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is a malignant pediatric brain tumor associated with dismal outcome. Recent high-throughput molecular studies have shown a high frequency of mutations in histone-encoding genes (H3F3A and HIST1B) and distinctive epigenetic alterations in these tu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Ahsan, Sama, Raabe, Eric H, Haffner, Michael C, Vaghasia, Ajay, Warren, Katherine E, Quezado, Martha, Ballester, Leomar Y, Nazarian, Javad, Eberhart, Charles G, Rodriguez, Fausto J
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229804/
https://ncbi.nlm.nih.gov/pubmed/24894482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-59
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge