Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia

Mid-life obesity and type 2 diabetes mellitus (T2DM) confer a modest, increased risk for Alzheimer’s disease (AD), though the underlying mechanisms are unknown. We have created a novel mouse model that recapitulates features of T2DM and AD by crossing morbidly obese and diabetic db/db mice with APP(...

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Sparad:
Bibliografiska uppgifter
I publikationen:Acta Neuropathol Commun
Huvudupphovsmän: Niedowicz, Dana M, Reeves, Valerie L, Platt, Thomas L, Kohler, Katharina, Beckett, Tina L, Powell, David K, Lee, Tiffany L, Sexton, Travis R, Song, Eun Suk, Brewer, Lawrence D, Latimer, Caitlin S, Kraner, Susan D, Larson, Kara L, Ozcan, Sabire, Norris, Christopher M, Hersh, Louis B, Porter, Nada M, Wilcock, Donna M, Murphy, Michael Paul
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229778/
https://ncbi.nlm.nih.gov/pubmed/24916066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-64
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