Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia

Mid-life obesity and type 2 diabetes mellitus (T2DM) confer a modest, increased risk for Alzheimer’s disease (AD), though the underlying mechanisms are unknown. We have created a novel mouse model that recapitulates features of T2DM and AD by crossing morbidly obese and diabetic db/db mice with APP(...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Niedowicz, Dana M, Reeves, Valerie L, Platt, Thomas L, Kohler, Katharina, Beckett, Tina L, Powell, David K, Lee, Tiffany L, Sexton, Travis R, Song, Eun Suk, Brewer, Lawrence D, Latimer, Caitlin S, Kraner, Susan D, Larson, Kara L, Ozcan, Sabire, Norris, Christopher M, Hersh, Louis B, Porter, Nada M, Wilcock, Donna M, Murphy, Michael Paul
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229778/
https://ncbi.nlm.nih.gov/pubmed/24916066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-64
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