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Obesity, Diabetes, and Leptin Resistance Promote Tau Pathology in a Mouse Model of Disease
Obesity and type 2 diabetes mellitus (T2DM) convey an increased risk for developing dementia. The microtubule associated protein tau is implicated in neurodegenerative disease by undergoing hyperphosphorylation and aggregation, leading to cytotoxicity and neurodegeneration. Enzymes involved in the r...
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| Publicado no: | Neuroscience |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4715963/ https://ncbi.nlm.nih.gov/pubmed/26701291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2015.12.011 |
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