Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10

BACKGROUND: Current treatment strategies for head and neck cancer are associated with significant morbidity and up to 50% of patients relapse, highlighting the need for more specific and effective therapeutics. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and Smac mimetics (SMs)...

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Foilsithe in:Br J Cancer
Main Authors: Raulf, N, El-Attar, R, Kulms, D, Lecis, D, Delia, D, Walczak, H, Papenfuss, K, Odell, E, Tavassoli, M
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2014
Ábhair:
Translational Therapeutics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229641/
https://ncbi.nlm.nih.gov/pubmed/25314064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.521
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