Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic–induced necroptosis

Caspase-8 (CASP8) is one of the most frequently mutated genes in head and neck squamous carcinomas (HNSCCs), and CASP8 mutations are associated with poor survival. The distribution of these mutations in HNSCCs suggests that they are likely to be inactivating. Inhibition of CASP8 has been reported to...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Uzunparmak, Burak, Gao, Meng, Lindemann, Antje, Erikson, Kelly, Wang, Li, Lin, Eric, Frank, Steven J., Gleber-Netto, Frederico O., Zhao, Mei, Skinner, Heath D., Newton, Jared, Sikora, Andrew G., Myers, Jeffrey N., Pickering, Curtis R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714407/
https://ncbi.nlm.nih.gov/pubmed/33108350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139837
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