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Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 (TRPM2) channels

OBJECTIVE: In vitro superoxide activates pulmonary endothelial TRPM2 channels and increases the capillary filtration coefficient (Kf). We hypothesized that pulmonary capillary Kf is increased in a model of type I diabetes due to elevated vascular superoxide and resultant TRPM2 channel activation. ME...

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Detaylı Bibliyografya
Yayımlandı:Microcirculation
Asıl Yazarlar: Lu, Silu, Xiang, Lusha, Clemmer, John S., Mittwede, Peter N., Hester, Robert L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229396/
https://ncbi.nlm.nih.gov/pubmed/25059284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/micc.12158
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