The Actin Targeting Compound Chondramide Inhibits Breast Cancer Metastasis via Reduction of Cellular Contractility

BACKGROUND: A major player in the process of metastasis is the actin cytoskeleton as it forms key structures in both invasion mechanisms, mesenchymal and amoeboid migration. We tested the actin binding compound Chondramide as potential anti-metastatic agent. METHODS: In vivo, the effect of Chondrami...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Menhofer, Magdalena H., Kubisch, Rebekka, Schreiner, Laura, Zorn, Matthias, Foerster, Florian, Mueller, Rolf, Raedler, Joachim O., Wagner, Ernst, Vollmar, Angelika M., Zahler, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229209/
https://ncbi.nlm.nih.gov/pubmed/25391145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112542
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