Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

Amyloid beta (Abeta) 1–42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor proteins is reported to inhibit long-term potentiation,...

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Pubblicato in:PLoS One
Autori principali: Izzo, Nicholas J., Xu, Jinbin, Zeng, Chenbo, Kirk, Molly J., Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Cruchaga, Carlos, Goate, Alison, Cahill, Michael A., Arancio, Ottavio, Mach, Robert H., Craven, Rolf, Head, Elizabeth, LeVine, Harry, Spires-Jones, Tara L., Catalano, Susan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229119/
https://ncbi.nlm.nih.gov/pubmed/25390692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111899
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