Sigma‐2 receptor antagonists rescue neuronal dysfunction induced by Parkinson’s patient brain‐derived α‐synuclein

α‐Synuclein oligomers are thought to have a pivotal role in sporadic and familial Parkinson's disease (PD) and related α‐synucleinopathies, causing dysregulation of protein trafficking, autophagy/lysosomal function, and protein clearance, as well as synaptic function impairment underlying motor...

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Detalhes bibliográficos
Publicado no:J Neurosci Res
Main Authors: Limegrover, Colleen S., Yurko, Raymond, Izzo, Nicholas J., LaBarbera, Kelsie M., Rehak, Courtney, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Catalano, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986605/
https://ncbi.nlm.nih.gov/pubmed/33480104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.24782
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