Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

Amyloid beta (Abeta) 1–42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor proteins is reported to inhibit long-term potentiation,...

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Bibliographic Details
Published in:PLoS One
Main Authors: Izzo, Nicholas J., Xu, Jinbin, Zeng, Chenbo, Kirk, Molly J., Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Cruchaga, Carlos, Goate, Alison, Cahill, Michael A., Arancio, Ottavio, Mach, Robert H., Craven, Rolf, Head, Elizabeth, LeVine, Harry, Spires-Jones, Tara L., Catalano, Susan M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229119/
https://ncbi.nlm.nih.gov/pubmed/25390692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111899
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