Proximal Tubule Epithelial Cell Specific Ablation of the Spermidine/Spermine N(1)-Acetyltransferase Gene Reduces the Severity of Renal Ischemia/Reperfusion Injury

BACKGROUND: Expression and activity of spermidine/spermine N(1)-acetyltransferase (SSAT) increases in kidneys subjected to ischemia/reperfusion (I/R) injury, while its ablation reduces the severity of such injuries. These results suggest that increased SSAT levels contribute to organ injury; however...

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Udgivet i:PLoS One
Main Authors: Zahedi, Kamyar, Barone, Sharon, Wang, Yang, Murray-Stewart, Tracy, Roy-Chaudhury, Prabir, Smith, Roger D., Casero, Robert A., Soleimani, Manoocher
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229091/
https://ncbi.nlm.nih.gov/pubmed/25390069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110161
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