Hepatocyte-specific ablation of spermine/spermidine-N(1)-acetyltransferase gene reduces the severity of CCl(4)-induced acute liver injury

Activation of spermine/spermidine-N(1)-acetyltransferase (SSAT) leads to DNA damage and growth arrest in mammalian cells, and its ablation reduces the severity of ischemic and endotoxic injuries. Here we have examined the role of SSAT in the pathogenesis of toxic liver injury caused by carbon tetrac...

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Hauptverfasser: Zahedi, Kamyar, Barone, Sharon L., Xu, Jie, Steinbergs, Nora, Schuster, Rebecca, Lentsch, Alex B., Amlal, Hassane, Wang, Jiang, Casero, Robert A., Soleimani, Manoocher
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2012
Schlagworte:
Liver and Biliary Tract
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468550/
https://ncbi.nlm.nih.gov/pubmed/22723264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00431.2011
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