Spermidine/spermine-N(1)-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice

Expression of spermine/spermidine-N(1)-acetyltransferase (SSAT), the rate-limiting enzyme of polyamine backconversion cascade, increases after ischemia-reperfusion injuries (IRI). We hypothesized that SSAT plays an important role in the mediation of IRI. To test our hypothesis, wild-type (SSAT-wt) a...

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Detalhes bibliográficos
Main Authors: Zahedi, Kamyar, Lentsch, Alex B., Okaya, Tomohisa, Barone, Sharon, Sakai, Nozomu, Witte, David P., Arend, Lois J., Alhonen, Leena, Jell, Jason, Jänne, Juhani, Porter, Carl W., Soleimani, Manoocher
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670665/
https://ncbi.nlm.nih.gov/pubmed/19164485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90507.2008
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