RAE-1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma

The immunoreceptor NKG2D originally identified in natural killer cells recognizes ligands that are upregulated on tumor cells. Expression of NKG2D ligands (NKG2DLs) is activated by the DNA damage response (DDR) which is often activated constitutively in cancer cells, revealing them to natural killer...

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Udgivet i:Cancer Res
Main Authors: Lam, Adeline R, Bert, Nina Le, Ho, Samantha SW, Shen, Yu J, Tang, Li FM, Xiong, Gordon M, Croxford, John L, Koo, Christine X, Ishii, Ken J, Akira, Shizuo, Raulet, David H, Gasser, Stephan
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229084/
https://ncbi.nlm.nih.gov/pubmed/24590060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1703
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