Unlocking a Caged Lysosomal Protein from a Polymeric Nanogel with a pH Trigger

[Image: see text] A polymeric nanogel has been used to sequester and turn off a lysosomal protein, acid α-glucosidase (GAA). The nanogel contains a β-thiopropionate cross-linker, which endows the nanogel with pH-sensitivity. While encapsulation of the enzyme fully turns off its activity, approximate...

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Bibliografiske detaljer
Udgivet i:Biomacromolecules
Main Authors: Molla, Mijanur Rahaman, Marcinko, Tyler, Prasad, Priyaa, Deming, Derrick, Garman, Scott C., Thayumanavan, S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229022/
https://ncbi.nlm.nih.gov/pubmed/25291086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm501091p
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