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Unlocking a Caged Lysosomal Protein from a Polymeric Nanogel with a pH Trigger
[Image: see text] A polymeric nanogel has been used to sequester and turn off a lysosomal protein, acid α-glucosidase (GAA). The nanogel contains a β-thiopropionate cross-linker, which endows the nanogel with pH-sensitivity. While encapsulation of the enzyme fully turns off its activity, approximate...
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| Publicado no: | Biomacromolecules |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4229022/ https://ncbi.nlm.nih.gov/pubmed/25291086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm501091p |
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