Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor

The interest in RNA modification enzymes surges due to their involvement in epigenetic phenomena. Here we present a particularly informative approach to investigate the interaction of dye-labeled RNA with modification enzymes. We investigated pseudouridine (Ψ) synthase TruB interacting with an alleg...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Spenkuch, Felix, Hinze, Gerald, Kellner, Stefanie, Kreutz, Christoph, Micura, Ronald, Basché, Thomas, Helm, Mark
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227767/
https://ncbi.nlm.nih.gov/pubmed/25300485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku908
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