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Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress
Werner syndrome (WS) is a human chromosomal instability disorder associated with cancer predisposition and caused by mutations in the WRN gene. WRN helicase activity is crucial in limiting breakage at common fragile sites (CFS), which are the preferential targets of genome instability in precancerou...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4227752/ https://ncbi.nlm.nih.gov/pubmed/25352544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1022 |
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