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ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells
Werner syndrome (WS) is a cancer-prone disease caused by deficiency of Werner protein (WRN). WRN maintains genome integrity by promoting replication-fork stability after various forms of replication stress. Under mild replication stress, WS cells show impaired ATR-mediated CHK1 activation. However,...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6468170/ https://ncbi.nlm.nih.gov/pubmed/30657978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz025 |
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