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Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function
In checkpoint-deficient cells, DNA double-strand breaks (DSBs) are produced during replication by the structure-specific endonuclease MUS81. The mechanism underlying MUS81-dependent cleavage, and the effect on chromosome integrity and viability of checkpoint deficient cells is only partly understood...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3814295/ https://ncbi.nlm.nih.gov/pubmed/24204313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003910 |
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