A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat

BACKGROUND: The positive transcription elongation factor b (P-TEFb) plays an essential role in activating HIV genome transcription. It is recruited to the HIV LTR promoter through an interaction between the Tat viral protein and its Cyclin T1 subunit. P-TEFb activity is inhibited by direct binding o...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Verstraete, Nina, Kuzmina, Alona, Diribarne, Gaelle, Nguyen, Van Trung, Kobbi, Lydia, Ludanyi, Monika, Taube, Ran, Bensaude, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227133/
https://ncbi.nlm.nih.gov/pubmed/24985203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-50
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