Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

The positive transcription elongation factor b (P-TEFb) plays a pivotal role in productive elongation of nascent RNA molecules by RNA polymerase II. Core active P-TEFb is composed of CDK9 and cyclin T. In addition, mammalian cell extracts contain an inactive P-TEFb complex composed of four component...

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Detalhes bibliográficos
Main Authors: Michels, Annemieke A, Fraldi, Alessandro, Li, Qintong, Adamson, Todd E, Bonnet, François, Nguyen, Van Trung, Sedore, Stanley C, Price, Jason P, Price, David H, Lania, Luigi, Bensaude, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC449783/
https://ncbi.nlm.nih.gov/pubmed/15201869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600275
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