Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

The positive transcription elongation factor b (P-TEFb) plays a pivotal role in productive elongation of nascent RNA molecules by RNA polymerase II. Core active P-TEFb is composed of CDK9 and cyclin T. In addition, mammalian cell extracts contain an inactive P-TEFb complex composed of four component...

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Dades bibliogràfiques

Publicat a:	EMBO J
Autors principals:	Michels, Annemieke A, Fraldi, Alessandro, Li, Qintong, Adamson, Todd E, Bonnet, François, Nguyen, Van Trung, Sedore, Stanley C, Price, Jason P, Price, David H, Lania, Luigi, Bensaude, Olivier
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2004
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449783/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15201869/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600275
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