Stability of the CpG island methylator phenotype during glioma progression and identification of methylated loci in secondary glioblastomas

BACKGROUND: Grade IV glioblastomas exist in two forms, primary (de novo) glioblastomas (pGBM) that arise without precursor lesions, and the less common secondary glioblastomas (sGBM) which develop from earlier lower grade lesions. Genetic heterogeneity between pGBM and sGBM has been documented as ha...

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Vydáno v:BMC Cancer
Hlavní autoři: Hill, Victoria K, Shinawi, Thoraia, Ricketts, Christopher J, Krex, Dietmar, Schackert, Gabriele, Bauer, Julien, Wei, Wenbin, Cruickshank, Garth, Maher, Eamonn R, Latif, Farida
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227105/
https://ncbi.nlm.nih.gov/pubmed/25012071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-506
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