Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage

Tyrosyl-tRNA synthetase (TyrRS) is known for its essential aminoacylation function in protein synthesis. Here we report a new function for TyrRS in DNA damage protection. We found that oxidative stress, which often down-regulates protein synthesis, induces TyrRS to rapidly translocate from the cytos...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Wei, Na, Shi, Yi, Truong, Lan N., Fisch, Kathleen M., Xu, Tao, Gardiner, Elisabeth, Fu, Guangsen, Hsu, Yun-Shiuan Olivia, Kishi, Shuji, Su, Andrew I., Wu, Xiaohua, Yang, Xiang-Lei
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224670/
https://ncbi.nlm.nih.gov/pubmed/25284223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.006
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