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Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion
Many cancer cells consume large quantities of glutamine to maintain TCA cycle anaplerosis and support cell survival. It was therefore surprising when RNAi screening revealed that suppression of citrate synthase (CS), the first TCA cycle enzyme, prevented glutamine-withdrawal-induced apoptosis. CS su...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Mol Cell |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4224619/ https://ncbi.nlm.nih.gov/pubmed/25242145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.018 |
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