Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

Many cancer cells consume large quantities of glutamine to maintain TCA cycle anaplerosis and support cell survival. It was therefore surprising when RNAi screening revealed that suppression of citrate synthase (CS), the first TCA cycle enzyme, prevented glutamine-withdrawal-induced apoptosis. CS su...

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書誌詳細
出版年:Mol Cell
主要な著者: Zhang, Ji, Fan, Jing, Venneti, Sriram, Cross, Justin R., Takagi, Toshimitsu, Bhinder, Bhavneet, Djaballah, Hakim, Kanai, Masayuki, Cheng, Emily H, Judkins, Alexander R., Pawel, Bruce, Baggs, Julie, Cherry, Sara, Rabinowitz, Joshua D., Thompson, Craig B.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224619/
https://ncbi.nlm.nih.gov/pubmed/25242145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.018
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