Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease

Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a common feature of numerous aging-related neurodegenerative diseases including Alzheimer’s disease (AD). However, the molecular mechanisms mediating tau truncation and aggregation during aging remain elusive. Her...

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Опубликовано в: :Nat Med
Главные авторы: Zhang, Zhentao, Song, Mingke, Liu, Xia, Kang, Seong Su, Kwon, Il-Sun, Duong, Duc M., Seyfried, Nicholas T., Hu, William T., Liu, Zhixue, Wang, Jian-zhi, Cheng, Liming, Sun, Yi E., Yu, Shan Ping, Levey, Allan I., Ye, Keqiang
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224595/
https://ncbi.nlm.nih.gov/pubmed/25326800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3700
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