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Mutant MMP-9 and HGF Gene Transfer Enhance Resolution of CCl(4)-Induced Liver Fibrosis in Rats: Role of ASH1 and EZH2 Methyltransferases Repression
Hepatocyte growth factor (HGF) gene transfer inhibits liver fibrosis by regulating aberrant cellular functions, while mutant matrix metalloproteinase-9 (mMMP-9) enhances matrix degradation by neutralizing the elevated tissue inhibitor of metalloproteinase-1 (TIMP-1). It was shown that ASH1 and EZH2...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4224431/ https://ncbi.nlm.nih.gov/pubmed/25380300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112384 |
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