Mutant MMP-9 and HGF Gene Transfer Enhance Resolution of CCl(4)-Induced Liver Fibrosis in Rats: Role of ASH1 and EZH2 Methyltransferases Repression

Hepatocyte growth factor (HGF) gene transfer inhibits liver fibrosis by regulating aberrant cellular functions, while mutant matrix metalloproteinase-9 (mMMP-9) enhances matrix degradation by neutralizing the elevated tissue inhibitor of metalloproteinase-1 (TIMP-1). It was shown that ASH1 and EZH2...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Atta, Hussein, El-Rehany, Mahmoud, Hammam, Olfat, Abdel-Ghany, Hend, Ramzy, Maggie, Roderfeld, Martin, Roeb, Elke, Al-Hendy, Ayman, Raheim, Salama Abdel, Allam, Hatem, Marey, Heba
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224431/
https://ncbi.nlm.nih.gov/pubmed/25380300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112384
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi