Mutant MMP-9 and HGF Gene Transfer Enhance Resolution of CCl(4)-Induced Liver Fibrosis in Rats: Role of ASH1 and EZH2 Methyltransferases Repression

Hepatocyte growth factor (HGF) gene transfer inhibits liver fibrosis by regulating aberrant cellular functions, while mutant matrix metalloproteinase-9 (mMMP-9) enhances matrix degradation by neutralizing the elevated tissue inhibitor of metalloproteinase-1 (TIMP-1). It was shown that ASH1 and EZH2...

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Udgivet i:PLoS One
Main Authors: Atta, Hussein, El-Rehany, Mahmoud, Hammam, Olfat, Abdel-Ghany, Hend, Ramzy, Maggie, Roderfeld, Martin, Roeb, Elke, Al-Hendy, Ayman, Raheim, Salama Abdel, Allam, Hatem, Marey, Heba
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224431/
https://ncbi.nlm.nih.gov/pubmed/25380300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112384
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