ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.
Examination of the structural basis for antiviral activity, oral pharmacokinetics, and hepatic metabolism among a series of symmetry-based inhibitors of the human immunodeficiency virus (HIV) protease led to the discovery of ABT-538, a promising experimental drug for the therapeutic intervention in...
Αποθηκεύτηκε σε:
| Εκδόθηκε σε: | Proc Natl Acad Sci U S A |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
1995
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42242/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7708670/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.7.2484 |
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