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In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 1 Variants with Increased Resistance to ABT-378, a Novel Protease Inhibitor

ABT-378, a new human immunodeficiency virus type 1 (HIV-1) protease inhibitor which is significantly more active than ritonavir in cell culture, is currently under investigation for the treatment of AIDS. Development of viral resistance to ABT-378 in vitro was studied by serial passage of HIV-1 (pNL...

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Detalhes bibliográficos
Main Authors: Carrillo, Alejandro, Stewart, Kent D., Sham, Hing L., Norbeck, Daniel W., Kohlbrenner, William E., Leonard, John M., Kempf, Dale J., Molla, Akhteruzzaman
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC109995/
https://ncbi.nlm.nih.gov/pubmed/9696850
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