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In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 1 Variants with Increased Resistance to ABT-378, a Novel Protease Inhibitor

ABT-378, a new human immunodeficiency virus type 1 (HIV-1) protease inhibitor which is significantly more active than ritonavir in cell culture, is currently under investigation for the treatment of AIDS. Development of viral resistance to ABT-378 in vitro was studied by serial passage of HIV-1 (pNL...

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Published in:J Virol
Main Authors: Carrillo, Alejandro, Stewart, Kent D., Sham, Hing L., Norbeck, Daniel W., Kohlbrenner, William E., Leonard, John M., Kempf, Dale J., Molla, Akhteruzzaman
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1998
Subjects:
Animal Viruses
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109995/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9696850/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.9.7532-7541.1998
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