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ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

Examination of the structural basis for antiviral activity, oral pharmacokinetics, and hepatic metabolism among a series of symmetry-based inhibitors of the human immunodeficiency virus (HIV) protease led to the discovery of ABT-538, a promising experimental drug for the therapeutic intervention in...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Kempf, D J, Marsh, K C, Denissen, J F, McDonald, E, Vasavanonda, S, Flentge, C A, Green, B E, Fino, L, Park, C H, Kong, X P
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42242/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7708670/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.7.2484
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