Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species

BACKGROUND: Metals including iron, copper and zinc are essential for physiological processes yet can be toxic at high concentrations. However the role of these metals in the progression of cancer is not well defined. Here we study the anti-tumor activity of the metal chelator, TPEN, and define its m...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:BMC Cancer
Prif Awduron: Fatfat, Maamoun, Merhi, Raghida Abou, Rahal, Omar, Stoyanovsky, Detcho A, Zaki, Angela, Haidar, Hazar, Kagan, Valerian E, Gali-Muhtasib, Hala, Machaca, Khaled
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223620/
https://ncbi.nlm.nih.gov/pubmed/25047035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-527
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