Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species

BACKGROUND: Metals including iron, copper and zinc are essential for physiological processes yet can be toxic at high concentrations. However the role of these metals in the progression of cancer is not well defined. Here we study the anti-tumor activity of the metal chelator, TPEN, and define its m...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Fatfat, Maamoun, Merhi, Raghida Abou, Rahal, Omar, Stoyanovsky, Detcho A, Zaki, Angela, Haidar, Hazar, Kagan, Valerian E, Gali-Muhtasib, Hala, Machaca, Khaled
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223620/
https://ncbi.nlm.nih.gov/pubmed/25047035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-527
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