Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells

Recently, we showed that the metal chelator TPEN targets colon cancer cells through redox cycling of copper. Here, we studied the DNA damage potential of TPEN and deciphered the role of Chk1, ATM and DNA-PK in TPEN-induced toxicity in 3 human colon cancer cell lines, HCT116, SW480 and HT29. We also...

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Bibliografische gegevens
Gepubliceerd in:Cancer Biol Ther
Hoofdauteurs: Rahal, Omar Nasser, Fatfat, Maamoun, Hankache, Carla, Osman, Bassam, Khalife, Hala, Machaca, Khaled, Muhtasib, Hala-Gali
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2016
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137490/
https://ncbi.nlm.nih.gov/pubmed/27690730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2016.1235658
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