Auxin-induced Rapid Degradation of Inhibitor of Caspase-activated DNase (ICAD) Induces Apoptotic DNA Fragmentation, Caspase Activation, and Cell Death: A CELL SUICIDE MODULE

Caspase-activated DNase (CAD) is a major apoptotic nuclease, responsible for DNA fragmentation and chromatin condensation during apoptosis. CAD is normally activated in apoptosis as a result of caspase cleavage of its inhibitory chaperone ICAD. Other aspects of CAD regulation are poorly understood....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Samejima, Kumiko, Ogawa, Hiromi, Ageichik, Alexander V., Peterson, Kevin L., Kaufmann, Scott H., Kanemaki, Masato T., Earnshaw, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223357/
https://ncbi.nlm.nih.gov/pubmed/25248749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.583542
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