Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein*

Pathogenic mutations in the amyloid precursor protein (APP) gene have been described as causing early onset familial Alzheimer disease (AD). We recently identified a rare APP variant encoding an alanine-to-threonine substitution at residue 673 (A673T) that confers protection against development of A...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Maloney, Janice A., Bainbridge, Travis, Gustafson, Amy, Zhang, Shuo, Kyauk, Roxanne, Steiner, Pascal, van der Brug, Marcel, Liu, Yichin, Ernst, James A., Watts, Ryan J., Atwal, Jasvinder K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Neurobiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223305/
https://ncbi.nlm.nih.gov/pubmed/25253696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589069
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