Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein

Alzheimer disease (AD) is associated with extracellular deposition of proteolytic fragments of amyloid precursor protein (APP). Although mutations in APP and proteases that mediate its processing are known to result in familial, early onset forms of AD, the mechanisms underlying the more common spor...

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Detalles Bibliográficos
Main Authors: Stieren, Emily S., El Ayadi, Amina, Xiao, Yao, Siller, Efraín, Landsverk, Megan L., Oberhauser, Andres F., Barral, José M., Boehning, Darren
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195644/
https://ncbi.nlm.nih.gov/pubmed/21852239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.243147
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