Kinesin-5 Allosteric Inhibitors Uncouple the Dynamics of Nucleotide, Microtubule, and Neck-Linker Binding Sites

Kinesin motor domains couple cycles of ATP hydrolysis to cycles of microtubule binding and conformational changes that result in directional force and movement on microtubules. The general principles of this mechanochemical coupling have been established; however, fundamental atomistic details of th...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Scarabelli, Guido, Grant, Barry J.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2014
Fag:
Proteins and Nucleic Acids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223232/
https://ncbi.nlm.nih.gov/pubmed/25418105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.09.019
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