Kinesin-5 Allosteric Inhibitors Uncouple the Dynamics of Nucleotide, Microtubule, and Neck-Linker Binding Sites

Kinesin motor domains couple cycles of ATP hydrolysis to cycles of microtubule binding and conformational changes that result in directional force and movement on microtubules. The general principles of this mechanochemical coupling have been established; however, fundamental atomistic details of th...

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Bibliographic Details
Published in:Biophys J
Main Authors: Scarabelli, Guido, Grant, Barry J.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2014
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223232/
https://ncbi.nlm.nih.gov/pubmed/25418105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.09.019
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